Publications listed alphabetically

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Bhaloo Z, Adams D, Liu Y, et al. Primary outcomes reporting in trials (PORTal): A systematic review of inadequate reporting in pediatric randomized controlled trials. J Clin Epidemiol. 2017;81:33-41.


Carlson LE, Zelinski EL, Speca M, Balneaves LG, Jones JM, Santa Mina D, Wayne PM, Campbell TS, Giese-Davis J, Faris P, Zwicker J, Patel K, Beattie TL, Cole S, Toivonen K, Nation J, Peng P, Thong B, Wong R, Vohra S. Protocol for the MATCH study: Mindfulness and Tai Chi for cancer health a preference-based multi-site randomized comparative effectiveness trial (CET) of Mindfulness-Based Cancer Recovery (MBCR) vs. Tai Chi/Qigong (TCQ) for cancer survivors. Contemp Clin Trials. 2017;59:64-76.


Jackman A, Mayan M, Kutt A, Vohra S. Perceptions of complementary health approaches among undergraduate healthcare professional trainees at a Canadian university. Eur J Integr Med. 2017;9:120-125.


Mirza RD, Punja S, Vohra S, Guyatt G. The history and development of N of 1 trials. JLL Bulletin: Commentaries on the history of treatment evaluation. 2017. Available at

Van Vliet KJ, Foskett AJ, Williams JL, Singhal A, Dolcos F, Vohra S. Impact of a mindfulness‚Äźbased stress reduction program from the perspective of adolescents with serious mental health concerns. Child Adolesc Ment Health. 2017;22(1):16-22.



Kutt A, Girard L, Necyk C, et al. Natural health product–drug interaction tool: A scoping review. Can Pharm J. 2016;149(2):75-82.

Li J, Gao W, Punja S, et al. Reporting quality of N-of-1 trials published between 1985 and 2013: A systematic review. J Clin Epidemiol. 2016;76:57-64.

Li G, Sajobi TT, Menon BK, et al. Registry-based randomized controlled trials-what are the advantages, challenges, and areas for future research? J Clin Epidemiol. 2016;80-16-24.

Necyk C, Khamba B, Chue P, Urichuk L, Snaterse M, Vohra S. Study of NHP-drug adverse reactions (SONAR) in patients seeking mental health services. Curr Med Res Opin. 2016:1-33.

Pohlman KA, Carroll L, Hartling L, Tsuyuki R, Vohra S. Attitudes and opinions of doctors of chiropractic specializing in pediatric care toward patient safety: A cross-sectional survey. J Manip Physiol Ther. 2016;39(7):487-493.

Pohlman KA, Carroll L, Hartling L, et al. Barriers to implementing a reporting and learning patient safety system pediatric chiropractic perspective. J Evid Based Complementary Altern Med. 2016. 21(2):105-9.

Punja S, Bukutu C, Shamseer L, et al. The design, analysis and meta-analysis of N-of-1 trials: A tapestry of heterogeneity. J Clin Epidemiol. 2016; 76:47-56.

Punja S, Schmid CH, Hartling L, et al. To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD. J Clin Epidemiol. 2016;76:76-81.

Punja S, Xu D, Schmid CH, et al. N-of-1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. J Clin Epidemiol. 2016;76:65-75.

Punja S, Shamseer L, Hartling L, et al. Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev. 2016;CD009996.

Punja S, Xu D, Schmid CH, et al. Amphetamines and methylphenidate for pediatric ADHD: A systematic review and meta-analysis of n-of-1 evidence. J Clin Epidemiol. 2016; 76:76-78.

Tate RL, Perdices M, Rosenkoetter U, et al. The single-case reporting guideline in BEhavioural interventions (SCRIBE) 2016 statement: Énoncé concernant la single-case reporting guideline in BEhavioural interventions (SCRIBE) 2016. Can J Occup Ther. 2016;83(3):184-195.

Tate RL, Perdices M, Rosenkoetter U, et al. The single-case reporting guideline in BEhavioural interventions (SCRIBE) 2016: Explanation and elaboration. Arch Sci Psychol. 2016;4(1):10-31.

Toupin April K, Stinson J, Boon H, et al. Development and Preliminary Face and Content Validation of the “Which Health Approaches and Treatments Are You Using?” (WHAT) Questionnaires Assessing Complementary and Alternative Medicine Use in Pediatric Rheumatology. PLoS ONE. 2016;11(3): e0149809.

Vohra S. An introduction to a series of papers about N-of-1 trials to enhance patient outcomes: Identifying effective therapies and reducing harms, one patient at a time. J Clin Epidemiol. 2016;76:6-9.

Vohra S, King-Jones S, SECTION ON INTEGRATIVE MEDICINE. Mind-Body Therapies in Children and Youth. Pediatrics. 2016;138(3): pii: e20161896.

Vohra S, Schlegelmilch M, Jou H, et al. Comparative effectiveness of pediatric integrative medicine as an adjunct to usual care for pediatric inpatients of a North American tertiary care centre: A study protocol for a pragmatic cluster controlled trial. Contemp Clin Trials Commun. 2016;5:12-18.

Zorzela L, Loke Yoon K, Ioannidis JP, et al. PRISMA harms checklist: improving harms reporting in systematic reviews. BMJ 2016; 352 :i157




Ardestani SK, Bukutu C, Vohra S. Therapeutic application of aromatherapy in pediatrics. In: Bagetta G, Cosentino M, Sakurada T, eds. Aromatherapy: Basic mechanisms and evidence based clinical use. CRC Press; 2015:347. 

Chitayat D, Matsui D, Amitai Y, et al. Folic acid supplementation for pregnant women and those planning pregnancy? 2015 update. J Clin Pharmacol. 2015 [epub ahead of print].

Crowden A, Guyatt G, Stepanov N, Vohra S. Research ethics and N-of-1 trials. In: Nikles J, Mitchell G, eds. The essential guide to N-of-1 trials in health. Springer Netherlands; 2015:125-133. 

Foster BC, Cvijovic K, Boon H, et al. Melatonin interaction resulting in severe sedation. J Pharm Pharm Sci. 2015;18(2):124-131.

Gutierrez E, Silbert-Flagg J, Vohra S. Management of natural health products in pediatrics: A provider-focused quality improvement project. J Pediatr Health Care. 2015;29(2):137-144.

Hughes C, Hydrie MZ, Vohra S. Interactions between antiretrovirals and natural health products. In: Watson RR, ed. Health of HIV infected people. Vol. 1 ed. London, UK: Elsevier Inc.; 2015:255-273.

Reilly MC, Vohra S, Rac VE, et al. Randomized trial of occlusive wrap for heat loss prevention in preterm infants. J Pediatr. 2015;166(2):262-268.e2.

Sampson M, A., Shamseer L, Vohra S. Reporting N-of-1 trials to professional audiences. In: Nikles J, Mitchell G, eds. The essential guide to N-of-1 trials in health. Springer Netherlands; 2015:175-194.

Shamseer L, Sampson M, Bukutu C, et al. CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration. BMJ. 2015;350.

Vohra S, Boon H. Advancing knowledge requires both clinical and basic research. Focus Altern Complement Ther. 2015;20(1):32-33. 

Vohra S, Shamseer L, Sampson M, et al. CONSORT extension for reporting N-of-1 trials (CENT) 2015 statement. BMJ. 2015;350:h1738.



Adams D, Schiffgen M, Kundu A, et al. Patterns of utilization of complementary and alternative medicine in two pediatric gastroenterology clinics. J Pediatr Gastroenterol Nutr. 2014;59(3):334-339.

Adams D, Whidden A, Honkanen M, Dagenais S, Clifford T, Baydala L,  King W, Hervas-Malo M, Vohra S. Complementary and Alternative Medicine: A Survey of its Use in Pediatric Cardiology. CMAJ Open. 2014;2(4):E217-E224.

Brulé D, Sule L, Landau-Halpern B, Nastase V, Jain U, Vohra S, Boon H. An open-label pilot study of homeopathic treatment of attention deficit hyperactivity disorder in children and youthForsch Komplementmed. 2014;21(5):302-309.

Galicia-Connolly E, Adams D, Bateman J, Dagenais S, Clifford T, Baydala L, King W, Vohra S. CAM use in pediatric neurology: an exploration of concurrent use with conventional medicine. PLoS ONE. 2014;9(4):e94078. doi: 10.1371/journal.pone.0094078

Gutierrez E, Silbert-Flagg J, Vohra S. Natural health product use and management in pediatrics: An integrative review. Eur J Integr Med. 2014;6(2):226-233.

McCall E, Alderdice F, Halliday H, Johnston L, Vohra S. Challenges of minimising heat loss at birth: A narrative overview of evidence-based thermal care interventions. Newborn Infant Nurs Rev. 2014; 14(2):56–63.

Necyk C, Tsuyuki R, Boon H, Foster B, LeGatt D, Cembrowski G, Murty M, Barnes J, Charrois T, Arnason J, Ware M, Rosychuk R, Vohra S. Pharmacy Study of Natural Health Product Adverse Reactions (SONAR): A cross-sectional study using Active Surveillance in Coummunity Pharmacies to Detect Adverse Events Assocaited with Natural Health Products and Assess Causality. BMJ Open. 2014;4:3 e003431. doi:10.1136/bmjopen-2013-003431

Pohlman KA, O'Beirne M, Thiel H, et al. Development and validation of providers' and patients' measurement instruments to evaluate adverse events after spinal manipulation therapy. Eur J Integr Med. 2014; 6(4):451-466.

Prinsen CA, Vohra S, Rose MR, et al. Core outcome measures in effectiveness trials (COMET) initiative: Protocol for an international delphi study to achieve consensus on how to select outcome measurement instruments for outcomes included in a'core outcome set'. Trials. 2014;15(1):247.

Punja S, Shamseer L, Olson K, Vohra S. Rhodiola rosea for mental and physical fatigue in nursing students: A randomized controlled trial. PLoS One. 2014;9(9):e108416.

Richmond E, Adams D, Dagenai S, Clifford T, Baydala L, King W, Vohra S. Complementary and Alternative Medicine: A survey of its use in Children with Chronic Respiratory Illness. Can J RespirTher. 2014; 50(1):1-6.

Rubin T, Clayton J, Adams D, Jou H, Vohra S. Systematic review of outcome measures in trials of pediatric anaphylaxis treatmentBMC Pediatrics. 2014;14(1):158.

Surette S, Vohra S. Complementary, holistic, and integrative medicine: Utilization surveys of the pediatric literature. Pediatr Rev. 2014;35(3):114-128.

Vohra S, Boon H. Getting answers on integrative medicinePolicy Options. 2014;35(5):72-73.

Vohra S, Kawchuk GN, Boon H, Caulfield T, Pohlman KA, O’Beirne M. SafetyNET: An interdisciplinary research program to support a safety culture for spinal manipulation therapy. Eur J Integr Med. 2014;6(4):473-477.

Zorzela L, Boon H, Mior S, et al. Serious adverse events associated with pediatric complementary and alternative medicine. Eur J Integr Med. 2014;6(4):467-472.

Zorzela L, Golder S, Liu Y, et al. Quality of reporting in systematic reviews of adverse events: Systematic review. BMJ. 2014;348:f7668.



Adams D, Dagenais S, Clifford T, Baydala L, King WJ, Hervas-Malo M, Moher D, Vohra S. Complementary and alternative medicine use by pediatric specialty outpatients. Pediatrics. 2013;131(2):225-32.

Adams D, Spelliscy C, Sivakumar L, et al. CAM and pediatric oncology: Where are all the best cases? Evid Based Complement Altern Med. 2013;2013:632351.

Dosman C, Adams D, Wudel B, Vogels L, Turner J, Vohra S. Complementary, holistic, and integrative medicine: Autism spectrum disorder and gluten-and casein-free diet. Pediatr Rev. 2013;34(10):e36-e41.

Gardiner P, Adams D, Filippelli AC, Nasser H, Saper R, White L, Vohra S. A systematic review of the reporting of adverse events associated with medical herb use among children. Glob Adv Health Med. 2013;2(2):58-67.

Grattan M, Thomas D, Hornberger L, Hamilton R, Midodzi W, Vohra S. Maternal hypothyroidism may be associated with congenital heart disease in offspring. Can J Cardiol. 2013;10(29):S144-S145. 

Necyk C, Barnes J, Tsuyuki R, Boon H, Vohra S. How well do pharmacists know their patients? A case report highlighting natural health product disclosure. Can Pharm J (Ott). 2013;146(4):202-209.

Necyk C, Ware MA, Arnason JT, Tsuyuki RT, Boon H, Vohra S. Increased bruising with the combination of long-chain omega-3 fatty acids, flaxseed oil and clopidogrel. Can Pharm J (Ott). 2013;146(2):93-96.

Punja S, Zorzela L, Hartling L, Urichuk L, Vohra S. Long-acting versus short-acting methylphenidate for paediatric ADHD: A systematic review and meta-analysis of comparative efficacy. BMJ Open. 2013;3(3).

Surette S, Vanderjagt L, Vohra S. Surveys of complementary and alternative medicine usage: A scoping study of the paediatric literature. Complement Ther Med. 2013;21 Suppl 1:S48-53 [2011 Sept epub ahead of print] doi:10.1016/j.ctim.2011.08.006

Surette S, Vohra S. The PedCAM Network: past, present, and future. Complement Ther Med.  2013;21(1):S70-S72 [2011 epub ahead of print] doi:10.1016/j.ctim.2011.03.002

Valji R, Adams D, Dagenais D, Clifford T, Baydala L, King WJ, Vohra S. Complementary and alternative medicine: A survey of its use in pediatric oncology. Evid Based Complement Altern Med. 2013;2013:527163. doi:10.1155/2013/527163

Vohra S, Punja S. N-of-1 trials: Individualized medication effectiveness tests. Virtual Mentor. 2013;15(1):42-45.

Vohra S, Reilly M, Rac VE, et al. Study protocol for multicentre randomized controlled trial of HeLP (heat loss prevention) in the delivery room. Contemp Clin Trials. 2013;36(1):54-60.

Wright J, Adams D, Vohra S. Complementary, holistic, and integrative medicine: Music for procedural pain. Pediatr Rev. 2013;34(11):e42-6.

Wynd S, Westaway M, Vohra S, Kawchuk G. The quality of reports on cervical arterial dissection following cervical spinal manipulation. PLoS ONE. 2013;8(3):e59170. doi:10.1371/journal.pone.0059170



Adams D, Wu T, Yasui Y, Aung S, Vohra S. Systematic reviews of TCM trials: how does inclusion of Chinese trials affect outcome? J Evidence-Based Med. 2012;5(2):89-97.

Erraguntla V, Serbanescu I, Vohra S, Abdolell M, McKneally MF, Levin AV. Parental comprehension following informed consent for pediatric cataract surgery. Can J Ophthalmol. 2012; 47(2):107-12.

Galicia-Connolly E, Shamseer L, Vohra S. Complementary, holistic, and integrative medicine: therapies for neurodevelopment in preterm infants. Pediatr Rev. 2012;(33)6:276-8.

Herxheimer A,Vohra S, Montastruc J, Edwards R. A major rethink is needed on reporting adverse drug reactions. BMJ. 2012;345:e6379.

Ishaque S, Shamseer L, Bukutu C, Vohra S. Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med. 2012, 12:70. doi:10.1186/1472-6882-12-70

Khamba B, Vohra S, Adams D, Neyck C. Natural health product interaction reporting with concurrent benzodiazepine use: A systematic review. Eur J Integrat Med 2012;4:96.

Mandziuk K, Liu Y, Adams D, Vohra S. Acupuncture for Cerebral Palsy. Focus Altern Complement Ther. 2012; 17(2): 85-90.

Punja S, Langevin M, Sencer S, Vohra S. Establishing a comprehensive pediatric integrative oncology program. In: Längler A, Mansky PJ, Seifert G, eds. Integrative Pediatric Oncology. Heidelberg, New York, Dortrecht, London: Springer Verlag; 2012:187-200.

Punja S, Shamseer L, Hartling L, et al. Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (protocol). Cochrane Database Syst Rev. 2012. DOI: 10.1002/14651858.CD009996

Scott O, Galcia-Connolly E, Adams D, Surette S, Vohra S, Yager J. The safety of cruciferous plants in humans: A systematic review. J Biomed Biotechnol. 2012; 28. doi:10.1155/2012/503241

Singhal A, Aaylor Shafer A, Russell M, Gibson B, Wang L, Vohra S, Dolcos F. Electrophysiological correlates of fearful and sad distraction on target processing in adolescents with attention deficit-hyperactivity symptoms and affective disorders. Front Integr Neurosci. 2012; 6: 119.

Toupin April K, Moher D, Stinson J, Byrne A, White M, Boon H, Duffy CM, Rader T, Vohra S, Tugwell P. Measurement properties of questionnaires assessing complementary and alternative medicine use in pediatrics: a systematic review. PLoS One. 2012;7(6):e39611.

Vohra S, Cvijovic K, Boon H, Foster BC, Jaeger W, Legatt D, Cembrowski G, Murty M, Tsuyuki RT, Barnes J, Charrois TL, Arnason JT, Necyk C, Ware M, Rosychuk RJ. Study of Natural Health Product Adverse Reactions (SONAR): Active surveillance of adverse events following concurrent natural health product and prescription drug use in community pharmacies. PLoS One. 2012;7(9):e45196. 

Vohra S, Moen A. Paediatric integrative medicine: developing the evidence we need to move forward. Focus Altern Complement Ther. 2012;17(2): 81-84.

Vohra S, Surette S, Mittra D, Rosen L, Gardiner P, Kemper K. Pediatric integrative medicine: Pediatrics' newest subspecialty? BMC Pediatrics. 2012;12(1):123.

Zorzela L, Hartling L, Joffe A, Punja S, Loke Y, Vohra S, Vandermeer B. Propofol infusion for paediatric sedation (protocol). Cochrane Database Syst Rev. 2012. DOI: 10.1002/14651858.CD009813



Adams, D, Cheng F, Jou H, Aung S, Vohra S. The safety of pediatric acupuncture: a systematic review. Pediatrics. 2011; 128(6):e1575-87. DOI: 10.1542/peds.2011-1091

Bateman J, Charrois T, Gardiner P, Vohra S. A descriptive study evaluating Health Canada's risk communications. Pharmacoepidemiol Drug Saf. 2011; 20(10): 1104–1109. doi: 10.1002/pds.2137

Cvijovic K, Boon H, Jaeger W, Vohra S. Polypharmacy, multiple natural health products and hepatotoxicity. CMAJ. 2011; 183(14):e1085-1089. [Epub 2011 Jul 4. doi:10.1503/cmaj.091948]

Galicia-Connolly EZ, Shamseer L, Vohra S. Complementary, holistic, and integrative medicine: therapies for learning disabilities. Pediatr Rev. 2011(32): e18-e24. doi: 10.1542/pir.32-2-e18.

Gabler NB, Duan N, Vohra S, Kravitz RL. N-of-1 trials in the medical literature: a systematic review. Med Care. 2011; 49(8): 761-768.

Gilmour J, Harrison C, Cohen M, Vohra S. Pediatric use of complementary and alternative medicine: legal, ethical and clinical issues in decision-making. Pediatrics. 2011; 128(Suppl. 4): S149-S154.

Gilmour J, Harrison C, Asadi L, Cohen M, Vohra S. Natural health product-drug interactions: evolving responsibilities to take complementary and alternative medicine into account. Pediatrics. 2011; 128(Suppl. 4): S155-S160.

Gilmour J, Harrison C, Asadi L, Cohen M, Vohra S. Treating teens: considerations when adolescents want to use complementary and alternative medicine. Pediatrics. 2011; 128(Suppl. 4):S161-S166.

Gilmour J, Harrison C, Asadi L, Vohra S. Childhood immunization: when physicians and parents disagree. Pediatrics. 2011; 128(Suppl. 4): S167-S174.

Gilmour J, Harrison C, Asadi L , Cohen M, Aung S, Vohra S. Considering complementary and alternative medicine alternatives in cases of life-threatening illness: applying the best interests test. Pediatrics. 2011; 128(Suppl. 4): S175-S180.

Gilmour J, Harrison C, Asadi L, Cohen M, Vohra S. Referrals and shared or collaborative care: managing relationships with complementary and alternative medicine practitioners. Pediatrics. 2011; 128(Suppl. 4): S181-186.

Gilmour J, Harrison C, Asadi L, Cohen M, Vohra S. Informed consent: advising patients and parents about complementary and alternative medicine therapies. Pediatrics. 2011; 128(Suppl. 4): S187-S192.

Gilmour J, Harrison C, Asadi L, Cohen M, Vohra S. Hospitals and complementary and alternative medicine: managing responsibilities, risk, and potential liability. Pediatrics. 2011; 128(Suppl. 4): S193-S199.

Gilmour J, Harrison C, Asadi L, Cohen M, Vohra S. Complementary and alternative medicine practitioners’ standard of care: responsibilities to patients and parents. Pediatrics. 2011; 128(Suppl. 4); S200-S205.

Gilmour J, Harrison C, Vohra S. Concluding comments: maximizing good patient care and minimizing potential liability when considering complementary and alternative medicine. Pediatrics. 2011; 128(Suppl. 4): S206-S212.

Goldman R, Vohra S, Rogovik A. Vitamin use among children attending a canadian pediatric emergency department. Fundam Clin Pharmacol. 2011;25(1):131.

Nikles J, Mitchell G, Hardy J, Good P, Rowett D, Shelby-James T, Schluter P, Currow DC, Vohra S. Aggregating single patient (n-of-1) trials in populations where recruitment and retention is difficult: the case of palliative care. J Clin Epidemiol. 2011; 64(5): 471-480. [epub ahead of print in 2010]

Tam T , Akhtar H, Arnason JT, Cvijovic K, Boon H, Cameron DW, Drouin CE, Jaeger W, Tsuyuki RT, Vohra S, Foster BC. Inhibition of human cytochrome P450 metabolism by blended herbal products and vitamins. J Pharm Pharm Sci. 2011; 14(1): 1-16.



Cvijovic K, Boon H, Jaeger W, Vohra S. Pharmacists’ participation in research: a case of trying to find the time. Int J Pharm Practice. 2010; 18(6):377-83. doi: 10.1111/j.2042-7174.2010.00067.x.

Johnston B, Shamseer L, daCosta B, Tsuyuki R, Vohra S. Measurement issues in trials of pediatric acute diarrheal diseases: a systematic review. Pediatrics. 2010; 126(1): e222-31.

McCall EM, Alderdice F, Halliday HL, Jenkins JG, Vohra S. Interventions to prevent hypothermia at birth in preterm and/or low birthweight infants. Cochrane Database Syst Rev. 2010;(1):CD004210. doi: 10.1002/14651858.CD004210.pub4

Rogovik A, Vohra S, Goldman R. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann Pharmacother. 2010; 44(2):311-324. doi: 10.1345/aph.1M238.

Shamseer L, Adams D, Brown N, Johnson JA, Vohra S. Antioxidant micronutrients for lung disease in cystic fibrosis. Cochrane Database Syst Rev. 2010;12:CD007020. doi: 10.1002/14651858.CD007020.pub2.